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Updated: May 18, 2026
09:04
In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging
Published on: June 8, 2017
Cerebral malaria: we have come a long way
Henry J Shikani1, Brandi D Freeman, Michael P Lisanti
1Division of Parasitology and Tropical Medicine, Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.
The American Journal of Pathology
|October 2, 2012
Summary
Cerebral malaria, a severe Plasmodium complication, causes long-term neurological issues in survivors despite treatment. Research in The American Journal of Pathology offers key insights into its damaging mechanisms and pathogenesis.
Area of Science:
- Neurology
- Infectious Diseases
- Pathology
Background:
- Cerebral malaria (CM) is a severe complication of Plasmodium infection, particularly impacting Sub-Saharan Africa.
- Survivors often experience long-term neurological deficits despite antiparasitic treatment.
Purpose of the Study:
- To review insights into cerebral malaria pathogenesis and mechanisms of brain damage.
- To highlight contributions from The American Journal of Pathology's research.
Main Methods:
- Review of original research published in The American Journal of Pathology.
- Analysis of studies from both human and experimental models of cerebral malaria.
Main Results:
- Studies have provided significant understanding of the mechanisms underlying cerebral damage in CM.
- Research has elucidated key aspects of CM pathogenesis.
Conclusions:
- Despite extensive research, cerebral malaria remains a significant global health challenge.
- Continued investigation into CM pathogenesis is crucial for mitigating neurological sequelae.
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