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Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography
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Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography

Published on: February 19, 2014

Relationship between clinical characteristics of polypoidal choroidal vasculopathy and choroidal vascular

Hideki Koizumi1, Tetsuya Yamagishi, Taizo Yamazaki

  • 1Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan. hidekoiz@koto.kpu-m.ac.jp

American Journal of Ophthalmology
|October 2, 2012
PubMed

Insights

Polypoidal choroidal vasculopathy (PCV) with choroidal vascular hyperpermeability is linked to bilateral membranes and poor ranibizumab response. These patients often have a history of central serous chorioretinopathy (CSC).

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Retinal Diseases

Background:

  • Polypoidal choroidal vasculopathy (PCV) is a subtype of age-related macular degeneration.
  • Choroidal vascular hyperpermeability is a key feature assessed via indocyanine green angiography (ICGA).
  • Understanding PCV characteristics is crucial for effective treatment strategies.

Purpose of the Study:

  • To determine the association between clinical features of PCV and choroidal vascular hyperpermeability.
  • To evaluate the relationship between hyperpermeability and patient history, clinical signs, and treatment outcomes.
  • To identify prognostic indicators in PCV patients.

Main Methods:

  • Retrospective analysis of 89 PCV patients' medical records and ICGA findings.
  • Evaluation of background factors, clinical manifestations, and response to intravitreal ranibizumab.
  • Statistical analysis to identify significant relationships (P-values reported).

Main Results:

  • Choroidal vascular hyperpermeability was present in 34.8% of PCV patients.
  • Hyperpermeability correlated with bilateral neovascular membranes (P=.009) and prior central serous chorioretinopathy (CSC) (P=.01).
  • Eyes with hyperpermeability showed increased subfoveal thickness (P < .001) and poorer response to ranibizumab (persistent fluid, P=.01).

Conclusions:

  • PCV patients with choroidal vascular hyperpermeability exhibit more bilateral neovascularization and a history of CSC.
  • These patients often present with thickened choroids and reduced treatment efficacy with ranibizumab.
  • Choroidal vascular hyperpermeability is a significant indicator of disease severity and treatment resistance in PCV.
Abstract

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