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Updated: May 18, 2026

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
Published on: September 15, 2017
Role of poly(ADP-ribose) polymerases in the regulation of inflammatory processes
1Department of Medical Chemistry, Medical and Health Science Center, University of Debrecen, Debrecen H-4032, Hungary. baip@med.unideb.hu
Abstract:
PARP enzymes influence the immune system at several key points and thus modulate inflammatory diseases. PARP enzymes affect immune cell maturation and differentiation and regulate the expression of inflammatory mediators such as cytokines, chemokines, inducible nitric oxide synthase and adhesion molecules. Moreover, PARP enzymes are key regulators of cell death during inflammation-related oxidative and nitrosative stress. Here we provide an overview of the different inflammatory diseases regulated by PARP enzymes.
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