Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Study Design in Statistics01:15

Study Design in Statistics

A study design is a set of techniques that allow a researcher to collect and analyze data from different variables defined for a specific research problem. Statistics is commonly for effective study design and more robust experiments,
Does aspirin reduce the risk of heart attacks? Is one brand of fertilizer more effective at growing roses than another? Is fatigue as dangerous to a driver as the influence of alcohol? Questions like these are answered using randomized experiments with proper...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Longitudinal Research02:20

Longitudinal Research

Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
Case Studies01:22

Case Studies

There are many research methods available to psychologists in their efforts to understand, describe, and explain behavior and the cognitive and biological processes that underlie it.
Study Designs in Epidemiology01:20

Study Designs in Epidemiology

Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and case-control studies.
Ethics in Research01:56

Ethics in Research

Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

METTL3 loss exacerbates colitis via m<sup>6</sup>A-dependent Slc39a8 regulation and epithelial lineage depletion.

Acta pharmacologica Sinica·2026
Same author

Effects of taurine supplementation on metabolic health and biological aging in healthcare workers: A protocol for a triple-blinded, Bayesian-optimized phase II randomized controlled trial.

PloS one·2026
Same author

Strand-asymmetric G-runs and G4s downstream of TSS modulate tumor suppressor gene transcription.

Oncogene·2026
Same author

To Do or Not to Do: Decompressive Craniectomy for Severe Traumatic Brain Injury.

Asian journal of neurosurgery·2026
Same author

Inflation of area under the receiver operating characteristic curve due to spectrum bias in case-control studies.

Anaesthesia and intensive care·2026
Same author

Strategies to enhance the likelihood of detecting true effects in randomised controlled trials.

Anaesthesia and intensive care·2026
Same journal

The Complementary Role of Size and Morphology in Predicting Intracranial Aneurysm Rupture: An Intra-Patient Matched Study.

World neurosurgery·2026
Same journal

Clinical Efficacy of Onyx Embolization in the Treatment of Distal Intracranial Microaneurysms.

World neurosurgery·2026
Same journal

Long-term Survival Rates in U.S. Veterans Shunted for iNPH: A Focused Analysis of Radiological Predictors.

World neurosurgery·2026
Same journal

Effects of Teriparatide on Complications and Surgical Outcomes in Patients Undergoing Correction of Adult Spinal Deformity: A Retrospective Cohort Study and Cost-Effectiveness Analysis.

World neurosurgery·2026
Same journal

ECG-Synchronized Physiological Feedback During Obex Cavernoma Surgery: 2-D Operative Video.

World neurosurgery·2026
Same journal

Functional Outcomes and Complications Following Very Delayed Cranioplasty: Clinical Challenges and Surgical Considerations.

World neurosurgery·2026
See all related articles

Related Experiment Video

Updated: May 18, 2026

A Flexible Platform for Monitoring Cerebellum-Dependent Sensory Associative Learning
11:32

A Flexible Platform for Monitoring Cerebellum-Dependent Sensory Associative Learning

Published on: January 19, 2022

What can be learned from the DECRA study.

Stephen Honeybul1, Kwok M Ho, Christopher R P Lind

  • 1Department of Neurosurgery, Sir Charles Gairdner Hospital, and School of Population Health, University of Western Australia, Perth, Western Australia, Australia. stephen.honeybul@health.wa.gov.au

World Neurosurgery
|October 2, 2012
PubMed
Summary
This summary is machine-generated.

Decompressive craniectomy for severe traumatic brain injury (TBI) may not improve outcomes. The DECRA study

More Related Videos

A Networked Desktop Virtual Reality Setup for Decision Science and Navigation Experiments with Multiple Participants
06:28

A Networked Desktop Virtual Reality Setup for Decision Science and Navigation Experiments with Multiple Participants

Published on: August 26, 2018

Related Experiment Videos

Last Updated: May 18, 2026

A Flexible Platform for Monitoring Cerebellum-Dependent Sensory Associative Learning
11:32

A Flexible Platform for Monitoring Cerebellum-Dependent Sensory Associative Learning

Published on: January 19, 2022

A Networked Desktop Virtual Reality Setup for Decision Science and Navigation Experiments with Multiple Participants
06:28

A Networked Desktop Virtual Reality Setup for Decision Science and Navigation Experiments with Multiple Participants

Published on: August 26, 2018

Area of Science:

  • Neurosurgery
  • Trauma Surgery
  • Critical Care Medicine

Background:

  • Decompressive craniectomy is increasingly used for severe traumatic brain injury (TBI).
  • While effective in reducing intracranial pressure (ICP), its clinical indications and patient selection remain debated.
  • Previous studies suggest potential for good long-term functional recovery in some patients.

Purpose of the Study:

  • To critically evaluate the findings of the DECRA study on early decompressive craniectomy for diffuse TBI.
  • To offer an alternative interpretation of the DECRA study data, considering methodological limitations.
  • To clarify the role of decompressive craniectomy in managing severe TBI.

Main Methods:

  • The DECRA study compared early decompressive craniectomy with standard medical therapy for severe TBI.
  • Methodological issues identified include randomization problems, an atypical ICP threshold, and high crossover rates.
  • An alternative interpretation of the study's basic data is presented.

Main Results:

  • The DECRA study reported unfavorable outcomes in 70% of the craniectomy group versus 51% in the standard care group.
  • Authors concluded craniectomy was associated with worse outcomes, but this is contested due to study limitations.
  • A transient, mild ICP increase may not indicate significant secondary brain injury, and surgical morbidity can offset benefits.

Conclusions:

  • The efficacy of decompressive craniectomy for persistent ICP elevation (≥20 mm Hg) requires further investigation.
  • The RESCUEicp study aims to address the unresolved questions regarding decompressive craniectomy's role in managing uncontrollable ICP.
  • Clinical practice should consider the limitations of the DECRA study when making treatment decisions for severe TBI.