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Asthma I: Introduction

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Allergic Reactions

Allergic Reactions

Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

Allergic Reactions: Anaphylaxis

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...

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Related Experiment Video

Updated: May 18, 2026

Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10

Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10

Published on: November 19, 2016

Does bedding affect the airway and allergy?

R W Siebers¹, J Crane

¹Wellington Asthma Research Group, Department of Medicine, School of Medicine and Health Sciences, University of Otago, Wellington, New Zealand. rob.siebers@otago.ac.nz

The International Journal of Occupational and Environmental Medicine

|October 2, 2012

Summary

This summary is machine-generated.

Synthetic bedding is linked to asthma and allergies, while feather bedding may protect against them. Higher dust mite levels in synthetic bedding are a potential cause, warranting further research into bedding

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Last Updated: May 18, 2026

Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10

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Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

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Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

Area of Science:

Environmental Health
Allergology
Epidemiology

Background:

Cross-sectional and longitudinal studies suggest a link between synthetic bedding and increased prevalence of asthma, allergic rhinitis, and eczema.
Feather bedding appears to have a protective effect against these allergic conditions.
Synthetic bedding often harbors higher levels of house dust mite allergens compared to feather bedding.

Purpose of the Study:

To review and discuss the epidemiological evidence associating bedding types with allergic diseases.
To explore potential mechanisms, including allergen exposure and other environmental factors, linking bedding to asthma and allergic conditions.
To highlight the need for intervention studies to confirm the protective role of feather bedding.

Main Methods:

Systematic review of existing epidemiological studies (cross-sectional and longitudinal).
Analysis of allergen levels in different bedding materials.
Discussion of potential contributing factors such as fungal and bacterial compounds and volatile organic compounds.
Evaluation of the current evidence base for intervention studies.

Main Results:

Consistent association found between synthetic bedding and increased risk of asthma, allergic rhinitis, and eczema.
Feather bedding is associated with a reduced risk or protective effect against these conditions.
Higher house dust mite allergen levels are identified in synthetic bedding, suggesting a primary mechanism.

Conclusions:

Feather bedding may be protective against the development of childhood asthma and allergic diseases.
Further primary intervention studies are needed to confirm the protective effects of feather bedding.
Secondary intervention studies are required to assess the potential of feather bedding in managing established allergic diseases and reducing medication use.