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Updated: May 18, 2026

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease
Published on: October 4, 2021
[Duodenal levodopa infusion for advanced Parkinson's disease in Finland 2006-2010]
Ville Pursiainen1, Eero Pekkonen
1Kansaneläkelaitos, terveysosasto.
Background:
Deep brain stimulation (DBS) has been used for treatment of advanced Parkinson's disease (PD) since 1990's. Duodenal levodopa infusion (DLI) has been available since 2006.
Materials And Methods:
Patient records of DLI patients and clinical data of DBS patients from 2006-2010 were requested from all university and central hospitals in Finland.
Results:
DLI was tested on 105 patients. 84 had a favourable response and were on long-term treatment. 85 patients underwent DBS operation. Technical problems and complications were common in DLI treated patients.
Conclusions:
DLI has become as popular as DBS in the treatment of advanced PD, but has a quite high complication rate.
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