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Published on: May 27, 2021
Celecoxib desensitization: continued temozolomide/celecoxib chemotherapy after a celecoxib-induced hypersensitivity
Guido J Burbach1, Peter Vajkoczy, Torsten Zuberbier
1Department of Dermatology, Charité-Universitätsmedizin Berlin, Berlin, Germany. guido.burbach@charite.de
Abstract:
Cox-2 inhibitors have been identified as promising candidates for cancer therapy. Several studies have recently proposed the use of celecoxib in long-term low-intensity chemotherapy protocols for recurrent tumors. However, drug-induced hypersensitivity reactions may force discontinuation of the medication and, thus, significantly complicate successful care. Here, we report on celecoxib desensitization after a celecoxib-induced skin reaction, thereby allowing the continuation of temozolomide/celecoxib chemotherapy in a young patient with recurrent astrocytoma.
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