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Updated: May 18, 2026
Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies
Published on: April 29, 2013
A novel combined imaging/morphometrical method for the analysis of human sural nerve biopsies for clinical diagnosis
Michele A Vonturkovich1, Marilyn P Wadsworth, William W Pendlebury
1Department of Pathology and Microscopy Imaging Center, College of Medicine, University of Vermont, Burlington, VT, USA.
Abstract:
Nerve Morphometry is one tool employed in the clinical assessment of peripheral sural nerve pathological abnormalities. A new method is presented in this chapter incorporating an unbiased approach to quantitative sural nerve evaluation. Using conventional epoxy embedded nerves processed for electron microscopy, confocal microscopy, and interactive digital assessment, this method produces a rigorous, accurate reproducible record for use in clinical diagnosis.
