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Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers
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Multiple resonance fiber-optic sensor with time division multiplexing for multianalyte detection.

Hsing-Ying Lin1, Chen-Han Huang, Chia-Chi Huang

  • 1Center for Nano Bio-Detection, National Chung Cheng University, 168 University Road, Chiayi 621, Taiwan.

Optics Letters
|October 3, 2012
PubMed
Summary
This summary is machine-generated.

This study demonstrates a novel fiber-optic sensor for detecting multiple analytes simultaneously using multiple particle plasmon resonance (PPR). The sensor achieves high sensitivity for real-time, label-free biomolecular detection.

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Area of Science:

  • * Nanophotonics and optical sensing
  • * Plasmonics and nanoscience
  • * Biochemical sensing technologies

Background:

  • * Fiber-optic sensors offer advantages for remote and in-situ measurements.
  • * Multiple Particle Plasmon Resonance (PPR) enables enhanced light-matter interactions.
  • * Simultaneous detection of multiple analytes is crucial for complex biological systems.

Purpose of the Study:

  • * To demonstrate a proof-of-concept multiwindow fiber-optic sensor for multianalyte detection.
  • * To utilize PPR of silver nanoparticles and gold nanorods for sensing.
  • * To enable simultaneous, real-time, and label-free monitoring of biomolecular interactions.

Main Methods:

  • * Fabricating a fiber-optic sensor with two unclad portions functionalized with silver nanoparticles and gold nanorods.
  • * Employing intensity interrogation of multiple wavelengths with a single detector.
  • * Utilizing time division multiplexing to modulate dual-wavelength LEDs for inducing PPRs.

Main Results:

  • * Achieved a refractive index resolution of 9 × 10⁻⁶ RIU.
  • * Demonstrated independent intensity response from two sensing windows to respective binding events.
  • * Successfully performed simultaneous, real-time, and label-free monitoring of two biomolecular interactions.

Conclusions:

  • * The multiwindow fiber-optic sensor architecture is effective for multianalyte detection.
  • * The sensor shows potential for cascaded, higher throughput, and advanced biochemical sensing applications.
  • * This approach offers a promising platform for label-free biosensing with enhanced sensitivity.