Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitosis and Cytokinesis01:35

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis And Cytokinesis01:35

Mitosis And Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Mitosis and Cytokinesis02:03

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...
Centrioles and Centrosomes01:13

Centrioles and Centrosomes

Most animal cells comprise a pair of centrioles together called a centrosome. The cell duplicates its centrosome and contains two centrosomes side-by-side, which begin to move apart during the prophase. As the centrosomes migrate to two different sides of the cell, microtubules start extending from each centrosome toward the other end. The mitotic spindle is composed of the centrosomes and their emerging microtubules.
Near the end of the prophase, also called late prophase or "prometaphase,"...
Microtubules in Cell Motility01:24

Microtubules in Cell Motility

Microtubules are thick hollow cylindrical proteins that help form the cytoskeleton. Microtubules have varied roles in the cell. These filaments help form cellular appendages like cilia and flagella, which are responsible for locomotion. The cilia arise from basal bodies, separated from the main body by a membrane-like structure forming the transition zone. This zone is the gate for the entry of lipids and proteins, creating a unique composition of lipids and proteins in the ciliary membrane and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A factor integrating transcription and repression of surface antigen genes in African trypanosomes.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Genomic evidence supports the "long chronology" for the peopling of Sahul.

Science advances·2025
Same author

Navigating the Narrative: Integrating Traditional Knowledge and Embodied Practice within Computational Models of Ancient Seafaring.

Journal of maritime archaeology·2025
Same author

Leveraging known Pacific colonisation times to test models for the ancestry of Southeast Asians.

Scientific reports·2025
Same author

A comprehensive toolkit for protein localization and functional analysis in trypanosomatids.

Open biology·2025
Same author

Comprehensive sub-mitochondrial protein map of the parasitic protist Trypanosoma brucei defines critical features of organellar biology.

Cell reports·2023

Related Experiment Video

Updated: May 18, 2026

Purification of Extracellular Trypanosomes, Including African, from Blood by Anion-Exchangers (Diethylaminoethyl-cellulose Columns)
14:26

Purification of Extracellular Trypanosomes, Including African, from Blood by Anion-Exchangers (Diethylaminoethyl-cellulose Columns)

Published on: April 6, 2019

Cytokinesis in trypanosomes.

Helen Farr1, Keith Gull

  • 1Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom. helen.farr@path.ox.ac.uk

Cytoskeleton (Hoboken, N.J.)
|October 3, 2012
PubMed
Summary
This summary is machine-generated.

Trypanosoma brucei uses microtubules, not actomyosin rings, for cell division (cytokinesis). This review explores its unique cellular architecture and regulatory systems, aided by advanced imaging techniques.

More Related Videos

Ultrastructural Expansion Microscopy in Three In Vitro Life Cycle Stages of Trypanosoma cruzi
09:45

Ultrastructural Expansion Microscopy in Three In Vitro Life Cycle Stages of Trypanosoma cruzi

Published on: May 12, 2023

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast
11:19

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast

Published on: February 20, 2017

Related Experiment Videos

Last Updated: May 18, 2026

Purification of Extracellular Trypanosomes, Including African, from Blood by Anion-Exchangers (Diethylaminoethyl-cellulose Columns)
14:26

Purification of Extracellular Trypanosomes, Including African, from Blood by Anion-Exchangers (Diethylaminoethyl-cellulose Columns)

Published on: April 6, 2019

Ultrastructural Expansion Microscopy in Three In Vitro Life Cycle Stages of Trypanosoma cruzi
09:45

Ultrastructural Expansion Microscopy in Three In Vitro Life Cycle Stages of Trypanosoma cruzi

Published on: May 12, 2023

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast
11:19

Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast

Published on: February 20, 2017

Area of Science:

  • Cell Biology
  • Parasitology
  • Microbiology

Background:

  • Cytokinesis is essential for cell division, typically involving an actomyosin contractile ring in eukaryotes.
  • The protozoan parasite Trypanosoma brucei exhibits an atypical cytokinesis mechanism.
  • Organelle replication and segregation are critical prerequisites for cell division.

Purpose of the Study:

  • To review the cellular architecture of Trypanosoma brucei and its role in cytokinesis.
  • To discuss recent advancements in understanding the regulatory systems governing trypanosome cytokinesis.
  • To highlight the impact of novel imaging techniques on studying parasite cell division.

Main Methods:

  • Review of existing literature on Trypanosoma brucei cell division.
  • Analysis of cellular architecture and organelle segregation processes.
  • Examination of recent findings from 3D imaging studies.

Main Results:

  • Trypanosoma brucei relies heavily on microtubules for cytokinesis, diverging from the typical actomyosin ring mechanism.
  • Specific preparatory steps involving organelle replication and segregation are crucial.
  • Advanced 3D imaging has provided new insights into the mechanics of cytokinesis.

Conclusions:

  • The unique microtubule-based mechanism in Trypanosoma brucei offers a distinct model for studying cytokinesis.
  • Further research utilizing advanced imaging will continue to elucidate the complexities of parasite cell division.
  • Understanding trypanosome cytokinesis is vital for parasite biology and potential therapeutic strategies.