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Molecular Factors Affecting Cell Division

Molecular Factors Affecting Cell Division

Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...

Interactions Between Signaling Pathways

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...

Mitogens and the Cell Cycle

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...

Mitogens and the Cell Cycle

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...

Notch Signaling Pathway

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...

Notch Signaling Pathway

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...

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Updated: May 18, 2026

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

Signaling pathways that regulate cell division.

Nicholas Rhind¹, Paul Russell

¹Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA. nick.rhind@umassmed.edu

Cold Spring Harbor Perspectives in Biology

|October 3, 2012

Summary

This summary is machine-generated.

Cell division relies on coordinated signaling pathways and checkpoints to ensure proper order and completion of mitotic events. These pathways, controlled by cyclin-dependent kinase 1 (CDK1), manage cell cycle progression and allow for arrests if errors occur.

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Area of Science:

Cell Biology
Molecular Biology
Biochemistry

Background:

Cell division involves precise execution of mitosis, chromosome segregation, and cytokinesis.
Cell cycle checkpoints are critical signaling pathways ensuring sequential event completion.
Feedback loops regulate commitment to division and event order.

Purpose of the Study:

To elucidate the role of signaling in coordinating cell division events.
To explain how cell division signaling differs from other signaling pathways.
To highlight the function of checkpoints in mitotic progression.

Main Methods:

Analysis of molecular signaling pathways governing cell division.
Review of checkpoint mechanisms and their regulation.
Examination of feedback loops in cell cycle control.

Main Results:

Cell division signaling primarily ensures completion of a G1-initiated decision for mitosis.
Signaling pathways entrain events to cyclin-dependent kinase 1 (CDK1) activation.
Checkpoints provide a mechanism to arrest division upon detecting errors.

Conclusions:

Cell division signaling is dedicated to executing and ordering mitotic events, rather than deciding whether to divide.
Cyclin-dependent kinase 1 (CDK1) is a central regulator of these signaling events.
Checkpoint proteins are essential for maintaining genomic integrity during cell division.