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Related Experiment Video

Updated: May 18, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

Hashimoto's encephalopathy.

Gouranga Santra¹, Dibyendu De, Sibaji Phaujdar

¹Dept. of Medicine, Medical College, 88 College Street, Kolkata-700073.

The Journal of the Association of Physicians of India

|October 4, 2012

Summary

Hashimoto's encephalopathy (HE), a rare neuroendocrine disorder linked to Hashimoto's thyroiditis (HT), can cause coma. Prompt steroid treatment is crucial for recovery in HE patients.

Area of Science:

Neurology
Endocrinology
Immunology

Background:

Hashimoto's encephalopathy (HE) is a rare, treatable neurological disorder associated with Hashimoto's thyroiditis (HT).
Neurological manifestations are common in thyroid disorders but HE is less documented.

Observation:

A 65-year-old female presented with sudden deep coma after fever and vomiting.
Metabolic, infectious, and structural causes were excluded; however, she had high anti-thyroid peroxidase (anti-TPO) antibodies.
Brain MRI showed diffuse atrophy, and EEG revealed diffuse slow waves.

Findings:

Intravenous dexamethasone initiated consciousness recovery over one month.
Azathioprine was added to reduce steroid toxicity while tapering the dose.
This case highlights HE as a treatable cause of coma.

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Implications:

HE should be considered in comatose patients with excluded common causes.
Early diagnosis and treatment with corticosteroids can lead to patient recovery.
Raising awareness of HE is vital for timely intervention and improved patient outcomes.