Related Experiment Video
Updated: May 18, 2026

Induction of Ocular Surface Inflammation and Collection of Involved Tissues
Published on: August 4, 2022
IgG4-positive sclerosing orbital inflammation involving the conjunctiva: a case report
Purpose:
To describe IgG4-positive sclerosing orbital inflammation with prominent conjunctival and scleral involvement.
Design:
Case report.
Methods:
Clinical, radiologic, and pathologic correlation.
Results:
A 66-year-old man presented with right eye redness and irritation. Examination revealed unilateral scleritis and nongranulomatous anterior uveitis with elevated p-ANCA and CRP. Orbital CT scan showed inferotemporal scleral thickening. Biopsy revealed sclerosis and IgG4-positive plasma cells in the conjunctiva and inferior rectus.
Conclusions:
IgG4-mediated sclerosing inflammation is well-recognized in the orbit and adnexa, particularly the lacrimal gland. Scleritis with anterior uveitis should be recognized as a possible presentation for this entity, which has important systemic associations.
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