Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Drug Classes and Categories01:25

Drug Classes and Categories

Drugs can be classified according to their chemical composition or their intended therapeutic application. For instance, anti-infective agents that possess the ability to eliminate pathogens or suppress their growth and reproduction can be grouped based on the organisms they target or their chemical structure. Furthermore, drugs can be divided into prescription, nonprescription, or controlled substances. Prescription medications, such as antibiotics, require oversight from a licensed healthcare...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Current State of Orthobiologics in Treatment of Knee Osteoarthritis-Future Directions.

International journal of molecular sciences·2026
Same author

Regenerative Medicine Approaches to Craniofacial and Corneal Neuropathic Pain.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

Correction: Brain-Centered Interventions for Nociplastic Pain: From Symptom Management to Pain Resolution.

Current pain and headache reports·2026
Same author

Brain-Centered Interventions for Nociplastic Pain: From Symptom Management to Pain Resolution.

Current pain and headache reports·2026
Same author

Epidemiology, Risk Factors, and Management of Pregnancy-Related Chronic Back Pain.

Current pain and headache reports·2026
Same author

The Lyceum for Pain Education: Providing Accessible Education on Chronic Pain and Headaches to a Global Audience.

Journal of pain research·2024
Same journal

Weight loss with atogepant in the long-term treatment of migraine: An interim analysis of a safety endpoint from a phase 3, multicenter, open-label, 156-week extension study.

Headache·2026
Same journal

American Headache Society 68th Annual Scientific Meeting June 4-7, 2026, Orlando, Florida.

Headache·2026
Same journal

In Memoriam-Doctor J. Keith Campbell.

Headache·2026
Same journal

Hypothalamus as a conductor of the migraine prodrome: A narrative review.

Headache·2026
Same journal

New academic year in Headache.

Headache·2026
Same journal

Essential readings in headache medicine: Top 10 educational articles from 2025.

Headache·2026
See all related articles

Related Experiment Videos

Risk stratification with opioid therapy.

Ronald J Kulich1, Melissa Stone

  • 1Harvard Medical School/Massachusetts General Hospital, Boston, MA 02129, USA.

Headache
|October 4, 2012
PubMed
Summary
This summary is machine-generated.

Chronic opioid therapy for persistent headaches is controversial due to risks. Careful patient screening and ongoing monitoring are crucial for safe opioid prescribing in headache management.

Related Experiment Videos

Area of Science:

  • Pain Management
  • Neuroscience
  • Pharmacology

Background:

  • Chronic opioid therapy for persistent headaches lacks robust supporting data and carries significant risks.
  • Societal risks, including diversion and substance abuse, are well-documented concerns.
  • Limited research exists on risk stratification specifically for opioid therapy in headache patients.

Purpose of the Study:

  • To review studies on risk stratification for chronic opioid therapy.
  • To identify specific risk factors associated with problematic opioid use in headache patients.
  • To inform recommendations for screening and patient management.

Main Methods:

  • Review of existing literature on risk stratification for chronic opioid therapy.
  • Extrapolation from other pain research due to limited headache-specific studies.
  • Analysis of clinical experience and empirical research.

Main Results:

  • Several risk factors can lead to problematic courses with chronic opioid therapy.
  • A comprehensive approach involving multiple assessment tools is necessary.
  • Continuous patient monitoring is essential for evaluating risk factors.

Conclusions:

  • Chronic opioid therapy for persistent headaches requires careful consideration of risks.
  • Risk stratification and ongoing monitoring are vital for safe prescribing practices.
  • Further research is needed to refine guidelines for opioid use in headache management.