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Endogenous anticoagulants

Amy Kubier1, Mauria O'Brien

  • 1University of Illinois Urbana-Champaign, Champaign, IL, USA. kubier@illinois.edu

Topics in Companion Animal Medicine
|October 4, 2012
PubMed

Blood coagulation is a complex and highly coordinated process that is constantly altered and impacted by procoagulant and anticoagulant "players." It is vital that these components work in concert to maintain a balance to keep coagulation in check. Several important endogenous anticoagulants will be discussed in this review including tissue factor pathway inhibitor, antithrombin, protein C, and protein S in origin, structure, mechanism of action, effects of deficiency, and current knowledge in veterinary medicine.

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