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Reinsemination in human IVF with fresh versus initial semen: a comparative study
J Ashkenazi1, D Feldberg, D Dicker
1Sherman Fertility Institute, Golda Meir Medical Center, Hashron Hospital, Petah Tikva, Israel.
Summary
Repeat insemination after initial IVF failure can be successful. Using fresh semen for reinsemination significantly improves fertilization, cleavage, and pregnancy rates compared to using initial semen.
Area of Science:
- Reproductive Medicine
- In Vitro Fertilization (IVF)
Background:
- Non-fertilization of oocytes in the first insemination during IVF is a clinical challenge.
- The efficacy of oocyte reinsemination in IVF remains a subject of debate.
Purpose of the Study:
- To evaluate the effectiveness of oocyte reinsemination in cases of initial fertilization failure.
- To compare the outcomes of using initial versus fresh semen for reinsemination in IVF.
Main Methods:
- A retrospective analysis of 132 women undergoing IVF for mechanical infertility.
- Patients requiring reinsemination were divided into two groups: Group I (initial semen) and Group II (fresh semen).
- Outcomes including fertilization, cleavage, and pregnancy rates were compared between the two groups.
Main Results:
- Reinsemination was required in 42% of treated women.
- Group II (fresh semen) demonstrated significantly higher fertilization rates (37.3%) compared to Group I (21.2%) (p < 0.005).
- Cleavage and pregnancy rates were also significantly higher in Group II (31.9% and 29.1%, respectively) than in Group I (18.6% and 18.4%, respectively) (p < 0.001 for both).
Conclusions:
- Oocyte reinsemination is a beneficial strategy following initial fertilization failure in IVF.
- The use of fresh semen for reinsemination is preferable to initial semen, leading to improved IVF success rates.