Interactions of marine-derived γ-pyrone natural products with phospholipid membranes
Kimberley J Powell1, Pallavi Sharma, Joanna L Richens
1School of Chemistry, University of Nottingham, Nottingham, England, UK.
Abstract:
The sacoglossan mollusc-derived metabolite, tridachiahydropyrone (3), and its proposed biosynthetic precursors (1 and 2) form part of a complex chemical defence system against predators and harmful UV light. Here, we provide supporting biophysical evidence that the metabolites become selectively localised at cell membranes and outline a binding scheme that accommodates the observed data. The possibility that localised lipid domains within the membrane have an effect on the localisation is also addressed.
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