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Updated: May 18, 2026
05:46
Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
Published on: April 9, 2014
Next-generation oral preexposure prophylaxis: beyond tenofovir
1Division of Infectious Diseases, Weill Cornell Medical Center, New York, NY, USA.
Current Opinion in HIV and AIDS
|October 4, 2012
Summary
Exploring new HIV pre-exposure prophylaxis (PrEP) options beyond tenofovir/emtricitabine is crucial. Alternative agents offer improved safety and efficacy for HIV prevention.
Area of Science:
- Infectious Diseases
- Pharmacology
- Virology
Background:
- Current oral pre-exposure prophylaxis (PrEP) primarily uses tenofovir (TDF) and emtricitabine (FTC).
- TDF is linked to potential renal and bone toxicities.
- FTC may contribute to drug resistance and is a first-line HIV treatment.
Purpose of the Study:
- To review alternative agents for HIV PrEP beyond the standard TDF/FTC regimen.
- To identify drugs with favorable safety, tolerability, and efficacy profiles for HIV prevention.
Main Methods:
- Literature review of existing and investigational agents for HIV PrEP.
- Analysis of drug characteristics including safety, tissue penetration, and dosing convenience.
Main Results:
- Five potential alternative agents for HIV PrEP were identified.
- Approved agents like maraviroc and raltegravir show promise.
- Investigational long-acting parenteral agents include rilpivirine, S/GSK1265744, and ibalizumab.
Conclusions:
- Future HIV PrEP strategies may involve a wider range of agents.
- Personalized selection of PrEP drugs based on patient needs will be possible.
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