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Related Concept Videos

Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...

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Related Experiment Video

Updated: May 18, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

Systemic contact dermatitis to corticosteroids.

M Baeck1, A Goossens

  • 1Department of Dermatology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium. marie.baeck@uclouvain.be

Allergy
|October 5, 2012
PubMed
Summary
This summary is machine-generated.

Allergic reactions to corticosteroids can occur through systemic administration, even in patients with known topical allergies. Most individuals react to various corticosteroid types, necessitating personalized testing for safe treatment.

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Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
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Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

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Last Updated: May 18, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

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Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:25

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

Area of Science:

  • Dermatology
  • Allergology
  • Pharmacology

Background:

  • Allergic hypersensitivity to corticosteroids, particularly delayed-type reactions, is a recognized clinical issue.
  • While skin exposure is the primary route for sensitization, systemic administration can exceptionally trigger reactions.

Purpose of the Study:

  • To investigate the incidence, clinical characteristics, and cross-reactivity patterns of allergic reactions to systemically administered corticosteroids.
  • Focus on patients with pre-existing contact allergy to corticosteroids.

Main Methods:

  • Retrospective review of clinical data, patch test results, and sensitization sources.
  • Study conducted over an 18-year period at a dermatology department.
  • Inclusion of patients with positive corticosteroid patch tests.

Main Results:

  • Sixteen out of 315 patients with delayed-type hypersensitivity to corticosteroids experienced allergic reactions from systemic administration.
  • Reactions involved corticosteroids from multiple groups within the current classification system.

Conclusions:

  • Systemic allergic reactions are often 'systemic contact dermatitis' from re-exposure to corticosteroids previously applied topically.
  • Patients frequently exhibit cross-reactivity to various corticosteroid molecules.
  • Individualized assessment of sensitization and tolerance profiles is crucial for managing corticosteroid allergies.