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Tyrosine kinase inhibitor induced pancreatitis

Adrienne Sevin1, Adrienne Chen, Brad Atkinson

  • 1University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. adrienneharris19@gmail.com

Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners
|October 5, 2012
PubMed

Insights

Sorafenib and sunitinib, tyrosine kinase inhibitors for metastatic renal cell carcinoma, can cause acute pancreatitis. This rare adverse event requires clinical attention in patients receiving these cancer therapies.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Sorafenib and sunitinib are oral tyrosine kinase inhibitors (TKIs).
  • These TKIs are standard treatments for metastatic renal cell carcinoma (mRCC).
  • Known side effects include hypertension and palmar-plantar erythrodysesthesia.

Observation:

  • Two cases of acute pancreatitis were observed.
  • The pancreatitis occurred in patients receiving TKIs.

Findings:

  • Acute pancreatitis is a potential adverse event associated with sorafenib and sunitinib.
  • This finding expands the known adverse event profile of these TKIs.

Implications:

  • Clinicians should consider acute pancreatitis in patients on TKIs presenting with relevant symptoms.
  • Further investigation into the TKI-pancreatitis association may be warranted.
Keywords:
Pancreatitissorafenibsunitinibtyrosine kinase inhibitor

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