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Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
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Metabolomics in the developing human being.

Aggeliki Syggelou1, Nicoletta Iacovidou, Luigi Atzori

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Metabolomics, the study of metabolites, offers a chemical fingerprint to understand dynamic biological systems. This review explores its use in understanding medical conditions in neonates and developing humans.

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Area of Science:

  • Biochemistry
  • Systems Biology
  • Medical Research

Background:

  • Metabolomics analyzes metabolites, providing a unique chemical fingerprint of biological systems.
  • It enables the assessment of dynamic behavior and complex network interactions within organisms.
  • Metabolic profiling has advanced significantly, with applications in toxicology, disease diagnosis, pharmacology, and nutrition.

Purpose of the Study:

  • To provide a comprehensive review of metabolomics applications in neonatology and developmental medicine.
  • To consolidate existing literature from animal and clinical studies.
  • To highlight the potential of metabolomics in understanding pediatric health and disease.

Main Methods:

  • Literature review of animal and clinical studies.
  • Analysis of data on metabolic profiling techniques.
  • Synthesis of findings related to medical conditions in neonates and developing humans.

Main Results:

  • Metabolomics has demonstrated utility across diverse research areas.
  • The field shows promise for advancing the understanding of neonatal and developmental conditions.
  • Existing data highlight the potential for improved diagnosis and classification of diseases.

Conclusions:

  • Metabolomics is a powerful tool for deciphering complex biological systems.
  • Its application in neonatology and developmental medicine is expanding.
  • Further research using metabolomics can lead to significant advancements in pediatric healthcare.