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Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
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Visual dominance and multisensory integration changes with age.

Andreea Oliviana Diaconescu1, Lynn Hasher, Anthony Randal McIntosh

  • 1Translational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zürich/ETH Zürich, Switzerland. andreeaoliviana.diaconescu@uzh.ch

Neuroimage
|October 6, 2012
PubMed
Summary
This summary is machine-generated.

Older adults may use enhanced multisensory integration, particularly in posterior parietal and medial prefrontal regions, to compensate for age-related cognitive declines, aiding object detection.

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Aging Research

Background:

  • Multisensory integration facilitates object recognition by linking visual and auditory information.
  • While some cognitive functions decline with age, changes in multisensory integration are not fully understood.

Purpose of the Study:

  • To investigate if multisensory integration plays a compensatory role in normal aging.
  • To examine age-related changes in the spatiotemporal dynamics of multisensory responses.

Main Methods:

  • Magnetoencephalography (MEG) recorded brain activity in young and older adults.
  • Stimuli included semantically related cross-modal (auditory-visual) and unimodal auditory/visual events.
  • Structural equation modeling analyzed the relationship between brain activity, detection speed, and gray matter volume.

Main Results:

  • Both age groups showed increased sensory-specific activity for cross-modal vs. unimodal stimuli.
  • Older adults exhibited preferential activation in posterior parietal and medial prefrontal regions for cross-modal stimuli.
  • Faster cross-modal detection in older adults correlated with increased activity in parietal/prefrontal regions and was mediated by gray matter volume.

Conclusions:

  • Multisensory integration processes are altered in normal aging.
  • Posterior parietal and medial prefrontal cortex activity supports cross-modal responses in older adults, potentially serving a compensatory function.
  • Age-related gray matter reductions in these regions mediate the link between enhanced neural activity and improved cross-modal performance.