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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

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Updated: May 18, 2026

Establishing a High Throughput Epidermal Spheroid Culture System to Model Keratinocyte Stem Cell Plasticity
10:03

Establishing a High Throughput Epidermal Spheroid Culture System to Model Keratinocyte Stem Cell Plasticity

Published on: January 30, 2021

Capturing epidermal stemness for regenerative medicine.

Yann Barrandon1, Nicolas Grasset, Andrea Zaffalon

  • 1Department of Experimental Surgery, Lausanne University Hospital, Switzerland. yann.barrandon@epfl.ch

Seminars in Cell & Developmental Biology
|October 6, 2012
PubMed
Summary
This summary is machine-generated.

Skin stem cells offer therapeutic potential for burns and wounds. Advances in gene therapy may treat inherited skin diseases, but challenges remain in efficacy, engraftment, and production costs.

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Related Experiment Videos

Last Updated: May 18, 2026

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Isolation and Culture of Adult Epithelial Stem Cells from Human Skin
08:26

Isolation and Culture of Adult Epithelial Stem Cells from Human Skin

Published on: March 31, 2011

Area of Science:

  • Dermatology and Regenerative Medicine
  • Stem Cell Biology
  • Biotechnology

Background:

  • Skin-derived stem cells (epithelial, mesenchymal, melanocyte) are valuable for therapeutic applications.
  • Current uses include burn coverage and chronic wound healing.
  • Gene therapy with keratinocyte stem cells shows promise for inherited skin diseases.

Purpose of the Study:

  • To review the therapeutic potential of skin stem cells.
  • To discuss challenges in clinical application and production.
  • To highlight future directions for improving efficacy and accessibility.

Main Methods:

  • Review of current literature on skin stem cell therapy.
  • Analysis of advancements in gene therapy and cell culture techniques.
  • Discussion of regulatory guidelines for medicinal cell products.

Main Results:

  • Skin stem cells are efficiently captured for therapeutic use.
  • Regulatory guidelines ensure safety and quality of cell products.
  • Clinical efficacy and autologous stem cell engraftment remain variable.

Conclusions:

  • Improving efficacy requires minimizing senescence and understanding engraftment mechanisms.
  • High production costs and reimbursement are significant barriers.
  • Further research is needed to optimize skin stem cell therapies.