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A Silicon-tipped Fiber-optic Sensing Platform with High Resolution and Fast Response
Published on: January 7, 2019
Tapered optical fiber sensor based on localized surface plasmon resonance.
Hsing-Ying Lin1, Chen-Han Huang, Gia-Ling Cheng
1Department of Photonics, National Cheng Kung University, Tainan 701, Taiwan.
Optics Express
|October 6, 2012
Summary
A novel tapered fiber localized surface plasmon resonance (LSPR) sensor enables sensitive refractive index and label-free biochemical detection. This compact biosensor shows potential for real-time biomolecular monitoring in various applications.
Area of Science:
- Photonics
- Nanotechnology
- Biomedical Engineering
Background:
- Localized surface plasmon resonance (LSPR) biosensors offer label-free detection capabilities.
- Tapered optical fibers provide a platform for evanescent field-based sensing.
- Integrating LSPR with tapered fibers can enhance sensitivity and miniaturization.
Purpose of the Study:
- To demonstrate a tapered fiber LSPR sensor for refractive index (RI) sensing.
- To evaluate the sensor's capability for label-free biochemical detection.
- To assess the sensor's potential for real-time biomolecular monitoring.
Main Methods:
- Fabrication of a tapered optical fiber coated with gold nanoparticles.
- Utilizing the evanescent field of the tapered fiber for LSPR excitation.
- Measuring transmission intensity changes for RI sensing.
- Functionalizing the sensor with DNP for antibody detection.
Main Results:
- Achieved a refractive index resolution of 3.2×10⁻⁵ RIU.
- Demonstrated label-free, real-time detection of anti-DNP antibodies.
- Confirmed the sensor's ability for both qualitative and quantitative biochemical analysis.
Conclusions:
- The tapered fiber LSPR sensor is effective for sensitive RI and biochemical detection.
- The compact and label-free nature of the sensor is advantageous for biomolecular applications.
- This technology holds promise for developing advanced biosensing platforms.
