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Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /(T1)Magnetic Resonance Imaging
Published on: November 20, 2018
MR characterization of focal nodular hyperplasia: gadoxetic acid versus superparamagnetic iron oxide imaging
Kazuhiro Saito1, Nobutaka Yoshimura, Toru Saguchi
1Department of Radiology, Tokyo Medical University, Tokyo, Japan. saito-k@tokyo-med.ac.jp
Purpose:
We evaluated the diagnostic efficacy of gadoxetic acid- and superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance (MR) imaging for focal nodular hyperplasia (FNH).
Materials And Methods:
We retrospectively evaluated 11 patients with 11 FNHs. Both gadoxetic acid- and SPIO-enhanced MR imaging were performed. A 3-dimensional (3D) volumetric interpolated breath-hold examination was used with the gadoxetic acid dynamic study. SPIO-enhanced MR imaging included T₂- and T₂*-weighted images. We quantitatively and qualitatively compared lesion-specific enhancement of both contrast media.
Results:
The mean signal-to-noise (S/N) ratio of the FNH lesions differed significantly on pre- and postenhanced imaging of each contrast medium (P<0.05); mean contrast-to-noise (C/N) ratio did not (P>0.05). All observers described all lesions as hyperintense in the arterial phase on gadoxetic acid-enhanced MR imaging and observed the presence of central scar, fibrous septa, and rim most clearly in gadoxetic acid-enhanced hepatobiliary phase images.
Conclusion:
Gadoxetic acid-enhanced MR imaging was more useful than SPIO-enhanced MR imaging in characterizing FNH.
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