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Updated: May 18, 2026

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Published on: August 2, 2018
The functional neuroanatomy of decision-making
Michael H Rosenbloom1, Jeremy D Schmahmann, Bruce H Price
1Center for Dementia and Alzheimer’s Care, Department of Neurology, HealthPartners, St. Paul, MN, USA. Michael.H.Rosenbloom@HealthPartners.com
This study explores the neural basis of decision-making, identifying key brain regions and their connections. It proposes an integrated neuroanatomical model and discusses clinical implications for neurological disorders.
Area of Science:
- Neuroscience
- Cognitive Psychology
Background:
- Decision-making is a complex executive function.
- It is influenced by experience, goals, emotions, and culture.
Purpose of the Study:
- To review the neuroanatomy of decision-making.
- To present an integrated neuroanatomical model.
- To discuss clinical relevance.
Main Methods:
- Functional imaging studies.
- Focal lesion studies.
- Literature review of prefrontal cortex connections.
Main Results:
- Orbitofrontal, anterior cingulate, and dorsolateral prefrontal cortices are critical.
- These regions connect with neocortex, limbic system, basal ganglia, and cerebellum.
Conclusions:
- An integrated neuroanatomical model for decision-making is proposed.
- Circuitry is relevant to frontotemporal dementia, traumatic brain injury, and sociopathy.
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