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Related Experiment Video

Updated: May 18, 2026

Microcrystallography of Protein Crystals and In Cellulo Diffraction
09:35

Microcrystallography of Protein Crystals and In Cellulo Diffraction

Published on: July 21, 2017

[Crystalline histiocytosis].

I G Rekhtina, E P Golitsina, V A Varshavskiĭ

    Terapevticheskii Arkhiv
    |October 9, 2012
    PubMed
    Summary

    This study details crystalline histiocytosis in a multiple myeloma patient, revealing intralysosomal crystals in kidney and bone marrow cells. Monoclonal IgG, not Bence-Jones protein, is implicated in crystal formation.

    Area of Science:

    • Nephrology
    • Hematology
    • Pathology

    Background:

    • Crystalline histiocytosis is a rare monoclonal secretion-associated disease.
    • This case involves a female patient diagnosed with multiple myeloma (MM).

    Observation:

    • Intralysosomal crystals were identified in bone marrow cells (histiocytes, plasmocytes) and kidney cells (mesangiocytes, podocytes).
    • Crystals were also found in a kidney graft, indicating systemic involvement.
    • Chemotherapy for MM led to reduced monoclonal IgG and Bence-Jones protein secretion.

    Findings:

    • Kidney graft function improved and stabilized following chemotherapy.
    • Despite reduced protein secretion, crystalline inclusions persisted in the kidney podocytes.
    • Monoclonal IgG is suggested as the primary factor in crystal formation pathogenesis.

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    Last Updated: May 18, 2026

    Microcrystallography of Protein Crystals and In Cellulo Diffraction
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    Implications:

    • This research highlights the role of monoclonal IgG in the pathogenesis of crystalline histiocytosis.
    • Understanding the specific protein involved can guide future therapeutic strategies for kidney and bone marrow involvement in MM.
    • Further investigation into IgG-mediated crystal deposition is warranted.