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Related Concept Videos

Transcytosis of IgG01:15

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...

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Isolation of Leukocytes from the Human Maternal-fetal Interface
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Interleukin-33 in the human placenta.

Vanessa Topping1, Roberto Romero, Nandor Gabor Than

  • 1Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, MD 20892, USA.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|October 9, 2012
PubMed
Summary
This summary is machine-generated.

Interleukin-33 (IL-33) is present in the human placenta, particularly in endothelial cells and macrophages. Its expression in placental tissues is linked to acute chorioamnionitis, indicating a role in pregnancy inflammation.

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Area of Science:

  • Reproductive immunology
  • Inflammation research
  • Cytokine signaling

Background:

  • Interleukin-33 (IL-33) is a key regulator of inflammation within the IL-1 cytokine family.
  • Understanding IL-33 expression in the placenta is crucial for investigating pregnancy-related inflammatory conditions.

Purpose of the Study:

  • To determine the expression of IL-33 in the human placenta.
  • To investigate IL-33 expression in the context of acute and chronic chorioamnionitis.

Main Methods:

  • Immunostaining of placental tissues from normal and complicated pregnancies (acute/chronic chorioamnionitis).
  • Analysis of IL-33 and IL1RL1 (ST2) mRNA expression in placental cells (AECs, AMCs, HUVECs) stimulated with IL-1β and CXCL10.

Main Results:

  • IL-33 protein was detected in placental endothelial cells, smooth muscle cells, CD14+ macrophages, and myofibroblasts.
  • Acute chorioamnionitis was associated with increased IL-33+ macrophages in membranes and umbilical cord.
  • IL-1β treatment increased IL-33 mRNA in mesenchymal cells and HUVECs, and modulated IL1RL1 (ST2) expression.

Conclusions:

  • IL-33 is expressed in various placental cell types, including endothelial cells and macrophages.
  • IL-33 protein is detectable in macrophages during acute chorioamnionitis, suggesting its involvement in this condition.
  • IL-1β can induce IL-33 and its receptor expression, highlighting a potential inflammatory pathway.