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Related Concept Videos

Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...

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Updated: Jul 7, 2026

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
05:53

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates

Published on: July 6, 2013

Early first-trimester CMV screening in a regional perinatal network: a multicenter descriptive study.

Virginie Collin-Bund1,2,3, Mathilde Pierrat1, Marie Zilliox1,2

  • 1Department of Gynecology and Obstetrics, University Hospitals of Strasbourg, Strasbourg, France.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|July 5, 2026
PubMed
Summary

Early screening for cytomegalovirus (CMV) in pregnant women identified infections and allowed management. While this regional approach enabled early detection, further studies are needed to assess its clinical effectiveness in preventing congenital CMV transmission.

Keywords:
CMVValaciclovircongenital infectioncytomegalovirusfirst trimester screening

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Area of Science:

  • Obstetrics and Gynecology
  • Infectious Diseases
  • Neonatology

Background:

  • Congenital cytomegalovirus (CMV) infection is the most common congenital infection globally.
  • Systematic first-trimester CMV screening in pregnancy is under debate, with France recommending nationwide screening in June 2025.
  • This study evaluated early CMV screening in a regional network before national implementation.

Purpose of the Study:

  • To describe maternal-fetal transmission, neonatal infection, and pregnancy outcomes after implementing early CMV screening.
  • To assess antenatal management strategies, including valaciclovir use.
  • To evaluate pregnancy outcomes in a real-world setting.

Main Methods:

  • Retrospective, multicenter observational study in three maternity units.
  • Included patients with primary CMV infection diagnosed periconceptionally or in the first trimester (up to 14 weeks gestation).
  • Analyzed maternal-fetal transmission rates, neonatal outcomes, and management strategies.

Main Results:

  • 38 primary CMV infections identified among 29,657 deliveries.
  • Valaciclovir used in 47% of cases; amniocentesis performed in 68%.
  • Congenital CMV infection rate was 10.5%; 3 newborns tested positive, and 1 pregnancy was terminated.

Conclusions:

  • Early CMV screening facilitated the identification and management of primary maternal infections in routine practice.
  • The descriptive nature and small sample size limit conclusions on clinical effectiveness or impact on vertical transmission.
  • Further research is needed to establish the efficacy of early screening programs.