Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: May 18, 2026

Orienteering as a Tool for Cognitive Research: An Implementation Guide

Orienteering as a Tool for Cognitive Research: An Implementation Guide

Published on: November 29, 2024

Resistance exercise enhances cognitive function in mouse.

K Suijo¹, S Inoue, Y Ohya

¹Department of Preventive Medicine and Public Health, Tokyo Medical University, Tokyo, Japan. suijo@tokyo-med.ac.jp

International Journal of Sports Medicine

|October 9, 2012

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Imaging of sub-surface defect in CFRP laminate using A<sub>0</sub>-mode Lamb wave: Analytical, numerical and experimental studies.

Ultrasonics·2022

Same author

Design of microfluidic channels to prevent negative filtration in implantable hemofiltration devices.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2021

Same author

Effect of oxaliplatin-based chemotherapy on chemosensitivity in patients with peritoneal metastasis from colorectal cancer treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: proof-of-concept study.

BJS open·2021

Same author

Downstaging of lymph node metastasis after neoadjuvant intraperitoneal and systemic chemotherapy in gastric carcinoma with peritoneal metastasis.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2019

Same author

Expression Pattern of Mitochondrial ND2 Gene in Human Leukemia and in HL60 Cells During Growth and Differentiation.

Leukemia & lymphoma·2016

Same author

Thymosin β4 Gene Expression in Leukemic Cells.

Leukemia & lymphoma·2016

Resistance exercise enhances cognition by increasing brain-derived neurotrophic factor (BDNF) and CREB in the hippocampus. This form of exercise also activates muscle protein synthesis pathways, suggesting broad benefits for brain health.

Area of Science:

Neuroscience
Exercise Physiology
Molecular Biology

Background:

Physical exercise, particularly aerobic, boosts adult neurogenesis and synaptic plasticity in the hippocampus.
The impact of resistance exercise on hippocampal plasticity molecules like BDNF and CREB is not well understood.
Aerobic exercise is known for its neuroprotective effects, but resistance exercise's effects on specific plasticity molecules require investigation.

Purpose of the Study:

To investigate whether resistance exercise (RE) influences brain-derived neurotrophic factor (BDNF) and CREB expression in the hippocampus.
To assess the effects of RE on learning and memory using the Morris water maze.
To examine RE's impact on the mammalian target of rapamycin (mTOR) and p70S6K signaling pathway in the soleus muscle.

Main Methods:

More Related Videos

Tracking Individual Running Metrics in Mice Using a Voluntary Wheel Running Protocol that Minimizes Social Isolation

Tracking Individual Running Metrics in Mice Using a Voluntary Wheel Running Protocol that Minimizes Social Isolation

Published on: April 18, 2025

Application of Passive Head Motion to Generate Defined Accelerations at the Heads of Rodents

Application of Passive Head Motion to Generate Defined Accelerations at the Heads of Rodents

Published on: July 21, 2022

Related Experiment Videos

Last Updated: May 18, 2026

Orienteering as a Tool for Cognitive Research: An Implementation Guide

Orienteering as a Tool for Cognitive Research: An Implementation Guide

Published on: November 29, 2024

Tracking Individual Running Metrics in Mice Using a Voluntary Wheel Running Protocol that Minimizes Social Isolation

Tracking Individual Running Metrics in Mice Using a Voluntary Wheel Running Protocol that Minimizes Social Isolation

Published on: April 18, 2025

Application of Passive Head Motion to Generate Defined Accelerations at the Heads of Rodents

Application of Passive Head Motion to Generate Defined Accelerations at the Heads of Rodents

Published on: July 21, 2022

Voluntary progressive-resistance wheel exercise (RE) was administered for 14 days.
Hippocampal levels of BDNF and CREB were measured.
Cognitive function was evaluated using the Morris water maze; muscle protein synthesis markers (mTOR, p70S6K) in the soleus were also assessed.

Main Results:

RE significantly enhanced cognitive function, as indicated by performance in the Morris water maze.
Hippocampal expressions of BDNF and CREB were elevated following RE.
RE activated the mTOR-p70S6K signaling pathway in the soleus muscle, with increased phosphorylated mTOR and p70S6K positively correlated with hippocampal BDNF expression.

Conclusions:

Resistance exercise promotes cognitive enhancement and increases key synaptic plasticity molecules (BDNF, CREB) in the hippocampus.
RE activates the muscle protein synthesis pathway (mTOR-p70S6K) in skeletal muscle.
The findings suggest a link between muscle adaptation and enhanced brain function, highlighting the beneficial effects of resistance exercise on cognitive health.