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Updated: May 18, 2026

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas
Published on: October 10, 2025
Interferon-α for unresectable progressive and symptomatic plexiform neurofibromas
Rejin Kebudi1, Fatma B Cakir, Omer Gorgun
1Division of Pediatric Hematology-Oncology, Cerrahpaşa Medical Faculty, and Oncology Institute, Istanbul University, Istanbul, Turkey.
Abstract:
Neurofibromas are the most common manifestations of neurofibromatosis type-1. They occasionally cause pain or progressive loss of function due to nerve compression. Optimal treatment approach is still challenging and the current treatment results are not satisfactory. Four cases of plexiform neurofibromas with various clinical presentations and an addendum to a previously published report on a patient who had relief from pain and/or regression of tumor volume after treatment with interferon-α 2a are presented.
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