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Updated: May 18, 2026

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
Published on: May 16, 2020
5-fluorouracil induced cardiotoxicity: review of the literature
Michael F Sorrentino1, Jiwon Kim, Andrew E Foderaro
1Department of Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA. msorrentino@lifespan.org
Abstract:
5-fluorouracil (5-FU) is a key chemotherapeutic agent in the treatment of many gastrointestinal tract adenocarcinomas. Despite its proven therapeutic efficacy, 5-FU also possesses several undesired cardiac toxicities, including coronary vasospasm, coronary thrombosis, cardiomyopathy, and sudden cardiac death. This review addresses the incidence, mechanisms of action, clinical presentation, risk stratification, and management of 5-FU associated cardiotoxicity; it also highlights the importance of careful pre-administration cardiac risk stratification and close monitoring during and after drug administration.
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