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NIS-catalyzed reactions: amidation of acetophenones and oxidative amination of propiophenones
Manjunath Lamani1, Kandikere Ramaiah Prabhu
1Department of Organic chemistry, Indian Institute of Science, Bangalore, Karnataka, India.
Abstract:
Single-step amination: the N-iodosuccinimide (NIS)-catalyzed amidation of acetophenone derivatives by using tert-butylhydroperoxide (TBHP) as an oxidant is presented. A variety of acetyl derivatives of heterocyclic compounds were easily converted to their corresponding ketoamides under these conditions. A new, NIS-catalyzed amination of propiophenone and its derivatives in the presence of TBHP to furnish the corresponding 2-aminoketone derivatives is the first reported single-step amination of propiophenone derivatives.
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