Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The association between body mass index and treatment outcomes in major depressive disorder: a CAN-BIND-1 study.

Journal of psychiatric research·2026
Same author

Addressing population and neurobiological diversity in TMS-EEG biomarker research.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2026
Same author

Insight into the impact of focal stimulation on large-scale network dynamics.

Journal of neural engineering·2026
Same author

Phase 1 Open-Label Pilot Trial of H4 Deep Repetitive Transcranial Magnetic Stimulation for Adults With Moderate-to-Severe Cannabis Use Disorder.

Neuromodulation : journal of the International Neuromodulation Society·2026
Same author

Clinical utility and prospective of TMS-EEG: Updated review from an international expert group.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2026
Same author

One-Year Actigraphy Study of Sleep and Rest-Activity Rhythms as Markers of Relapse in Depression.

JAMA psychiatry·2026

Related Experiment Video

Updated: May 18, 2026

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
08:23

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

Disrupted cortical conductivity in schizophrenia: TMS-EEG study.

Marina Frantseva1, Jie Cui, Faranak Farzan

  • 1Schizophrenia Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

Cerebral Cortex (New York, N.Y. : 1991)
|October 9, 2012
PubMed
Summary

Schizophrenia involves abnormal brain network activity. Transcranial magnetic stimulation (TMS) revealed excessive, widespread cortical activation in schizophrenia patients, linked to symptom severity.

Keywords:
connectivityelectroencephalographyneuronal synchronyschizophreniatranscranial magnetic stimulation

More Related Videos

Neuroimaging-Guided TMS–EEG for Real-Time Cortical Network Mapping
09:55

Neuroimaging-Guided TMS–EEG for Real-Time Cortical Network Mapping

Published on: June 13, 2025

Combined Transcranial Magnetic Stimulation and Electroencephalography of the Dorsolateral Prefrontal Cortex
07:42

Combined Transcranial Magnetic Stimulation and Electroencephalography of the Dorsolateral Prefrontal Cortex

Published on: August 17, 2018

Related Experiment Videos

Last Updated: May 18, 2026

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
08:23

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

Neuroimaging-Guided TMS–EEG for Real-Time Cortical Network Mapping
09:55

Neuroimaging-Guided TMS–EEG for Real-Time Cortical Network Mapping

Published on: June 13, 2025

Combined Transcranial Magnetic Stimulation and Electroencephalography of the Dorsolateral Prefrontal Cortex
07:42

Combined Transcranial Magnetic Stimulation and Electroencephalography of the Dorsolateral Prefrontal Cortex

Published on: August 17, 2018

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Science

Background:

  • Schizophrenia is characterized by cognitive integration failures and altered neurocircuit oscillatory properties.
  • Abnormal neural network characteristics may disrupt functional connectivity and signal propagation in schizophrenia.

Purpose of the Study:

  • To investigate differences in electroencephalography (EEG) responses to transcranial magnetic stimulation (TMS) between schizophrenia patients and healthy controls.
  • To explore the relationship between altered cortical activation patterns and schizophrenia symptomology.

Main Methods:

  • EEG recordings were used to measure cortical responses to TMS of the motor cortex in individuals with schizophrenia and healthy subjects.
  • Analysis focused on the propagation and oscillatory characteristics of TMS-induced neural activation.

Main Results:

  • No significant differences were found in the initial TMS response between groups.
  • Schizophrenia patients exhibited widespread, recurrent cortical activation post-TMS, unlike healthy controls where activation subsided.
  • Increased gamma band activation correlated with positive symptoms, while theta and delta band activation correlated with negative symptoms.

Conclusions:

  • Excessive cortical activation in response to stimulation may underlie aberrant signal propagation in schizophrenia.
  • This mechanism could contribute to positive symptoms and cognitive deficits by disrupting information processing and exacerbating signal-to-noise ratio issues.