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Characterization of urinary peptic activity after total gastrectomy
T Yamaguchi1, T Takahashi, M Kodama
1First Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
The Japanese Journal of Surgery
|January 1, 1990
Summary
Urinary peptic activity, previously thought to be gastric-exclusive, was found in patients without a stomach. This suggests extra-gastric production of pepsinogen I, a key digestive enzyme.
Area of Science:
- Gastroenterology
- Biochemistry
- Urology
Background:
- Peptic activity in urine was traditionally attributed solely to gastric mucosa.
- The presence and origin of peptic activity in urine post-gastrectomy remained unclear.
Purpose of the Study:
- To investigate the presence and source of peptic activity in the urine of patients who underwent total gastrectomy.
- To determine if pepsinogen I is produced outside the stomach.
Main Methods:
- Analysis of urinary peptic activity using gel filtration and electrophoresis in gastrectomized patients.
- Quantification of pepsinogen I in urine and serum via radioimmunoassay.
Main Results:
- Peptic activity was detected in 26 of 50 gastrectomized patients.
- Electrophoresis indicated urinary peptic activity matched group I pepsinogen.
- Pepsinogen I was found in the urine of all tested gastrectomized patients and in most serum samples.
- Urinary peptic activity correlated significantly with urinary pepsinogen I levels.
Conclusions:
- Urinary peptic activity after total gastrectomy originates from pepsinogen I.
- These findings strongly suggest extra-gastric production of pepsinogen I.