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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

[Transfusion in children with sickle cell disease]

M-L Couëc1

  • 1Service d'hématologie pédiatrique, CHU de Nantes, 7, quai Moncousu, 44093 Nantes cedex 1, France. marielaure.couec@chu-nantes.fr

Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine
|October 10, 2012
PubMed

Sickle cell disease is a genetic hemoglobinopathy characterised by vasoocclusive events and chronic haemolytic anaemia. Transfusion is a major therapeutic modality in this disease by decreasing the percentage of abnormal haemoglobin Hb S while increasing oxygen carrying capacity. Simple transfusions or exchange transfusions can be indicated occasionally or on a chronic transfusion program. Iron overload, vascular access and alloimmunization to erythrocyte antigens are causes of great concern in these young patients.

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