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Nonhuman primates as animal models for toxicology research
1University of Washington, Seattle, Washington, USA.
Current Protocols in Toxicology
|October 10, 2012
Summary
Nonhuman primates are vital in toxicology research, aiding studies in reproductive health, neural development, immune function, lung health, and cancer. This review highlights their extensive applications in understanding chemical impacts on biological systems.
Area of Science:
- Toxicology
- Primate Research
- Chemical Safety
Background:
- Nonhuman primates have a long-standing history in toxicological research.
- Their use is critical for understanding complex biological responses to chemical exposures.
Purpose of the Study:
- To review the diverse applications of nonhuman primates in various fields of toxicology.
- To consolidate information on primate models in toxicological research.
Main Methods:
- Literature review of studies utilizing nonhuman primates in toxicology.
- Categorization of applications across different toxicological sub-disciplines.
Main Results:
- Applications span reproductive toxicology and teratology.
- Significant use in neural, neurobehavioral, and immunotoxicology.
- Primate models are employed in respiratory toxicology and chemical carcinogenesis research.
Conclusions:
- Nonhuman primates serve as indispensable models in comprehensive toxicological assessments.
- Their use provides critical data for human health risk evaluation across multiple organ systems and disease areas.
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