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Updated: May 17, 2026

DNA Microarrays: Sample Quality Control, Array Hybridization and Scanning
Published on: March 15, 2011
DNA microarrays: an overview of technologies and applications to toxicology
1N.I.E.H.S./University of Washington Center for Ecogenetics and Environmental Health and Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Abstract:
DNA microarrays or chips can be used to simultaneously monitor the expression levels and/or genotypes of thousands of genes. The application of these techniques heralds a new era in toxicology research, where genotypes and toxicant-induced expression signatures may be used to monitor cellular responses to different doses, to classify toxins on the basis of their mechanisms of action, to monitor exposures, and to predict individual variability in toxicant sensitivity. This unit reviews the current state of microarray technologies and discusses potential applications in toxicology, with emphasis on the strengths and limitations of the technologies.
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