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Role of Skin in Vitamin D Synthesis

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).

Role of Vitamins in Maintaining Bone Health

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
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Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
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Connective Tissue Cell Types

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Related Experiment Video

Updated: May 17, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

Vitamin D and overall mortality.

Aliana Guerrieri-Gonzaga¹, Sara Gandini

¹Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy.

Pigment Cell & Melanoma Research

|October 11, 2012

Summary

Low vitamin D levels are linked to increased chronic disease risk and mortality. While supplements may reduce mortality, more research is needed to confirm vitamin D

Area of Science:

Endocrinology
Genetics
Epidemiology

Background:

Vitamin D, a skin-produced steroid hormone, regulates gene expression.
Low vitamin D serum levels are globally prevalent and associated with chronic diseases and mortality.
Existing meta-analyses suggest a link between low vitamin D and increased health risks.

Purpose of the Study:

To evaluate the association between vitamin D levels and chronic disease risk.
To investigate the impact of vitamin D supplementation on total mortality rates.
To identify the need for further research on long-term effects and causality.

Main Methods:

Review of epidemiological studies and meta-analyses.
Analysis of data from healthy subjects regarding vitamin D supplementation.

Related Experiment Videos

Last Updated: May 17, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

Identification of ongoing and needed clinical trials.

Main Results:

Epidemiological evidence suggests low vitamin D is a risk factor for chronic diseases and mortality.
A meta-analysis indicated vitamin D supplements might decrease total mortality in healthy individuals.
Causality between vitamin D and all-cause mortality remains unproven.

Conclusions:

Further investigation is required to establish a causal link between vitamin D and non-skeletal health outcomes.
Long-term health effects of high-dose vitamin D supplementation need further study.
Large-scale, placebo-controlled randomized trials with mortality as the primary endpoint are necessary.