Linear atrophoderma of Moulin: a distinct entity?

Area of Science:

• Dermatology
• Pathology

Background:

• Linear atrophoderma of Moulin (LAM) is a rare condition with hyperpigmented atrophoderma following Blaschko lines.
• Clinical and histological similarities exist between LAM, atrophoderma of Pasini and Pierini (APP), and morphea, leading to debate about their classification.
• The relationship between these conditions is often considered a spectrum of disorders.

Observation:

• A 16-year-old boy presented with clinical features supporting LAM, including lesions along Blaschko lines and perivascular lymphocytic infiltrate on biopsy.
• The patient exhibited bilateral lesions characteristic of APP and collagen entrapment of eccrine ducts seen in morphea.
• Histological examination revealed changes in dermal collagen consistent with features across all three conditions.

Findings:

• The case supports the hypothesis that LAM, APP, and morphea represent a spectrum of related disorders rather than distinct entities.
• The patient's presentation integrated features of LAM, APP, and morphea, suggesting a continuum of disease.
• A literature review indicates an evolving definition of LAM, incorporating features of APP and morphea.

Implications:

• This case contributes to understanding the potential spectrum encompassing LAM, APP, and morphea.
• Recognizing these conditions as a spectrum may refine diagnostic criteria and treatment approaches.
• Further research is warranted to elucidate the precise relationship and underlying mechanisms of these dermatologic disorders.