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Updated: May 17, 2026
10:37
Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
Published on: November 30, 2016
Focus on irritable bowel syndrome.
1Department of Internal Medicine, University of Naples, Italy.
European Review for Medical and Pharmacological Sciences
|October 11, 2012
Summary
Irritable Bowel Syndrome (IBS) involves abnormal gut motility, gas, and pain sensitivity. Immune system dysfunction and altered enteric nervous system signaling are key factors in IBS pathogenesis.
Area of Science:
- Gastroenterology
- Neurogastroenterology
- Immunology
Background:
- Irritable Bowel Syndrome (IBS) is a complex functional gastrointestinal disorder.
- Symptoms include chronic abdominal discomfort and altered bowel habits without identifiable organic causes.
- Recent research highlights novel insights into IBS pathogenesis.
Purpose of the Study:
- To review recent findings on the pathogenesis of Irritable Bowel Syndrome (IBS).
- To explore the roles of abnormal intestinal motility, gas production, and visceral hypersensitivity.
- To examine the involvement of the enteric nervous system (ENS) and immune system in IBS.
Main Methods:
- Literature review of recent scientific findings.
- Analysis of studies investigating the enteric nervous system (ENS) in IBS.
- Examination of research on immune system alterations and inflammation in IBS patients.
Main Results:
- Dysfunction of the enteric nervous system (ENS) is implicated, with altered expression of receptors like TRPV1, ASIC3, P2X3r, TTRX2, and PPARs.
- The immune system shows altered cellular composition and activation in IBS subjects.
- Inflammation and immune dysregulation impact nerve fiber sensitivity.
Conclusions:
- Abnormal intestinal motility, gas production, and enhanced nociception are key mechanisms in IBS.
- Enteric nervous system (ENS) dysfunction, evidenced by altered receptor expression, plays a significant role.
- Immune system impairment and inflammation are critical factors influencing IBS symptoms and warrant further therapeutic development.
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