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Related Concept Videos

Irritable Bowel Syndrome01:23

Irritable Bowel Syndrome

DefinitionIrritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent combinations of abdominal pain, bloating, diarrhea, or constipation.Pathophysiology of irritable bowel syndromeIts pathophysiology is multifactorial, involving disturbances in motility, sensory processing, microbial balance, barrier integrity, and gut–brain communication. These mechanisms interact to produce symptoms that vary across IBS subtypes.Altered Motility PatternsDisordered...
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Irritable Bowel Syndrome III: Medical and Nursing Management01:30

Irritable Bowel Syndrome III: Medical and Nursing Management

Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

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Related Experiment Video

Updated: May 17, 2026

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
10:37

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform

Published on: November 30, 2016

Focus on irritable bowel syndrome.

A Scalera1, C Loguercio

  • 1Department of Internal Medicine, University of Naples, Italy.

European Review for Medical and Pharmacological Sciences
|October 11, 2012
PubMed
Summary

Irritable Bowel Syndrome (IBS) involves abnormal gut motility, gas, and pain sensitivity. Immune system dysfunction and altered enteric nervous system signaling are key factors in IBS pathogenesis.

Area of Science:

  • Gastroenterology
  • Neurogastroenterology
  • Immunology

Background:

  • Irritable Bowel Syndrome (IBS) is a complex functional gastrointestinal disorder.
  • Symptoms include chronic abdominal discomfort and altered bowel habits without identifiable organic causes.
  • Recent research highlights novel insights into IBS pathogenesis.

Purpose of the Study:

  • To review recent findings on the pathogenesis of Irritable Bowel Syndrome (IBS).
  • To explore the roles of abnormal intestinal motility, gas production, and visceral hypersensitivity.
  • To examine the involvement of the enteric nervous system (ENS) and immune system in IBS.

Main Methods:

  • Literature review of recent scientific findings.
  • Analysis of studies investigating the enteric nervous system (ENS) in IBS.

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Using An In Vitro Tissue Perfusion System to Detect the Functional Activities of Isolated Intestinal Tubes in Real Time

Published on: July 26, 2024

Related Experiment Videos

Last Updated: May 17, 2026

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
10:37

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform

Published on: November 30, 2016

Using An In Vitro Tissue Perfusion System to Detect the Functional Activities of Isolated Intestinal Tubes in Real Time
06:01

Using An In Vitro Tissue Perfusion System to Detect the Functional Activities of Isolated Intestinal Tubes in Real Time

Published on: July 26, 2024

  • Examination of research on immune system alterations and inflammation in IBS patients.

    • Main Results:

    • Dysfunction of the enteric nervous system (ENS) is implicated, with altered expression of receptors like TRPV1, ASIC3, P2X3r, TTRX2, and PPARs.
    • The immune system shows altered cellular composition and activation in IBS subjects.
    • Inflammation and immune dysregulation impact nerve fiber sensitivity.

    Conclusions:

    • Abnormal intestinal motility, gas production, and enhanced nociception are key mechanisms in IBS.
    • Enteric nervous system (ENS) dysfunction, evidenced by altered receptor expression, plays a significant role.
    • Immune system impairment and inflammation are critical factors influencing IBS symptoms and warrant further therapeutic development.