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Amperozide--effect on prolactin release in the rat.
A Albinsson1, E Eriksson, G Andersson
1Pharmacia LEO Therapeutics AB, Department of CNS-Research, Malmö, Sweden.
Pharmacology & Toxicology
|January 1, 1990
Summary
Amperozide, an antipsychotic, significantly lowered prolactin levels in rats. This effect was not due to direct action on pituitary cells, suggesting a central mechanism for amperozide
Area of Science:
- Neuropharmacology
- Endocrinology
Background:
- Amperozide is a novel drug with potential antipsychotic properties.
- Prolactin secretion is regulated by complex neuroendocrine pathways.
Purpose of the Study:
- To investigate the effect of amperozide on prolactin release in a rat model.
- To determine if amperozide acts directly on pituitary lactotrophs.
Main Methods:
- Rats were treated with amperozide.
- Plasma prolactin concentrations were measured at 30 minutes post-treatment.
- Prolactin release from isolated rat pituitary cells was assessed in vitro.
Main Results:
- Amperozide significantly decreased plasma prolactin levels in vivo.
- Amperozide did not affect prolactin release from isolated pituitary cells.
Conclusions:
- The in vivo reduction in prolactin by amperozide is not mediated by a direct effect on pituitary lactotrophs.
- The mechanism of action for amperozide's effect on prolactin secretion likely involves higher central nervous system levels.