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Circulating DNA and NSCLC: old findings with new perspectives

Raquel Catarino1, Ana Coelho, Rui Medeiros

  • 1Molecular Oncology Group Investigation Center, Portuguese Institute of Oncology, Porto, Portugal;

Journal of Thoracic Disease
|October 11, 2012
PubMed
Summary

No abstract available in PubMed .

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...