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Related Experiment Video

Updated: May 17, 2026

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Published on: August 4, 2021

[Recurrent miscarriage--causes, diagnostics and treatment].

Elisabeth Clare Larsen¹, Ole Bjarne Christiansen

¹Fertilitetsklinikken, Afsnit 4071, Juliane Marie Centret, Rigshospitalet, Blegdamsvej 9, Copenhagen. elisabeth.clare.larsen@rh.regionh.dk

Ugeskrift for Laeger

|October 12, 2012

Summary

Recurrent miscarriage (RM), three or more pregnancy losses, is multifactorial. Evaluation includes genetic, uterine, hormonal, and immune testing, with treatments targeting specific causes needing more research.

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Area of Science:

Reproductive Medicine
Genetics
Immunology

Context:

Recurrent miscarriage (RM) affects 1% of couples, defined as three or more consecutive early pregnancy losses.
RM is a complex condition with likely multiple contributing factors.
Current understanding suggests a multifactorial etiology for RM.

Purpose:

To outline the comprehensive evaluation and management strategies for recurrent miscarriage.
To highlight the diagnostic workup for couples experiencing RM.
To discuss potential treatments for RM based on identified underlying causes.

Summary:

Evaluation for RM involves parental karyotyping, uterine anomaly assessment, thyroid function tests, thrombophilia screening, and immune factor analysis.
Supportive care includes serial hCG measurements and ultrasound monitoring.
Treatment options address specific causes, such as surgery, hormone therapy, anticoagulation, and immunomodulation.

Impact:

Provides a framework for diagnosing and managing recurrent miscarriage.
Identifies areas where further research is needed to validate treatment efficacy.
Aims to improve outcomes for couples affected by recurrent pregnancy loss.