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Chronic obstructive pulmonary disease as a cardiovascular risk factor. Results of a case-control study (CONSISTE

Pilar de Lucas-Ramos1, Jose Luis Izquierdo-Alonso, Jose Miguel Rodriguez-Gonzalez Moro

  • 1Servicio de Neumologia, Hospital General Universitario Gregorio Maranon, Madrid, Spain. pilar.delucas@gmail.com

International Journal of Chronic Obstructive Pulmonary Disease
|October 12, 2012
PubMed

Insights

Chronic obstructive pulmonary disease (COPD) significantly increases the risk of cardiovascular diseases, including ischemic heart disease, cerebrovascular disease, and peripheral vascular disease. This study confirms COPD as an independent risk factor for cardiovascular comorbidity.

Area of Science:

  • Cardiology
  • Pulmonology
  • Epidemiology

Background:

  • Patients with chronic obstructive pulmonary disease (COPD) exhibit a high prevalence of cardiovascular disease (CVD).
  • The co-occurrence of COPD and CVD may stem from shared pathogenic mechanisms or common risk factors.
  • Investigating the independent contribution of COPD to CVD is crucial for understanding this comorbidity.

Purpose of the Study:

  • To compare cardiovascular comorbidity rates in COPD patients versus control subjects.
  • To ascertain if COPD itself is an independent risk factor for cardiovascular disease.

Main Methods:

  • A multicenter, cross-sectional, case-control study design was employed.
  • The study included 1200 patients diagnosed with COPD and 300 healthy control subjects.
  • Statistical analyses included univariate and multivariate risk assessments.

Main Results:

  • COPD patients demonstrated significantly higher prevalence of ischemic heart disease (12.5% vs. 4.7%), cerebrovascular disease (10% vs. 2%), and peripheral vascular disease (16.4% vs. 4.1%) compared to controls.
  • Univariate analysis identified COPD, hypertension, diabetes, obesity, and dyslipidemia as risk factors for ischemic heart disease.
  • Multivariate analysis confirmed COPD as an independent risk factor for ischemic heart disease (OR: 2.23; 95% CI: 1.18-4.24; P = 0.014).

Conclusions:

  • COPD patients exhibit a significantly elevated prevalence of cardiovascular disease.
  • This prevalence exceeds expectations based on age and the presence of traditional cardiovascular risk factors.
  • COPD is established as an independent risk factor for cardiovascular comorbidity.
Abstract

Keywords:
COPDcardiovascular riskischemic heart disease

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