Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammation01:38

Inflammation

Overview
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Advancing Cardiogeriatric Care and Frailty Science in Cardiovascular Disease: From Basic Science to Implementation.

Heart, lung & circulation·2026
Same author

Challenges of Intra-Aortic Balloon Pump and Extracorporeal Membrane Oxygenation in Cardiogenic Shock: Real-World Outcomes.

Acta Cardiologica Sinica·2026
Same author

Heart Diseases Can Predict Incident Frailty: A 20-Year Cohort Study in 3,998 Older Adults.

Heart, lung & circulation·2026
Same author

Effects of a music-visual guided physical activity promotion program for adults with intellectual disability in supported care settings: a cluster-randomized controlled trial.

The international journal of behavioral nutrition and physical activity·2026
Same author

Partial Duodeno-Ileal Diversion with Magnetic Compression Anastomosis: A Novel Approach for the Treatment of Type 1 Diabetes-Associated Metabolic Derangements in a Porcine Model.

Obesity surgery·2026
Same author

Portable Electrical Impedance Tomography Enables Heart Ejection Fraction Measurement for Health Screening in Nonspecialist Settings.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

Physiological load and breath-holding in artistic swimming: a scoping review establishing historical baselines and evidence gaps in the context of the 2022-2025 rule changes.

Frontiers in physiology·2026
Same journal

Effects of blood flow restriction exercise interventions on patellofemoral pain syndrome: a systematic review and meta-analysis.

Frontiers in physiology·2026
Same journal

Effects of resistance-type and cycling-type high-intensity interval training on cardiorespiratory fitness, lower-body strength, and anaerobic fitness.

Frontiers in physiology·2026
Same journal

Model-based estimates of sex differences in peak power and fatigue index in track cyclists using directed acyclic graphs, inverse probability of treatment weighting, and Bayesian modeling.

Frontiers in physiology·2026
Same journal

Fine-tuning striated muscle performance: conserved sarcomere-level mechanisms across insect and vertebrate systems.

Frontiers in physiology·2026
Same journal

Effects of different dual-task trainings on gait and cortical activation during obstacle crossing in stroke patients: a randomized controlled trial.

Frontiers in physiology·2026
See all related articles

Related Experiment Video

Updated: May 17, 2026

Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis
07:05

Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis

Published on: May 17, 2015

Macrophages in collateral arteriogenesis.

Erik Fung1, Armin Helisch

  • 1Department of Medicine, Heart and Vascular Center, Dartmouth-Hitchcock Medical Center Lebanon, NH, USA.

Frontiers in Physiology
|October 12, 2012
PubMed
Summary
This summary is machine-generated.

Monocytes and macrophages play a key role in collateral artery growth (arteriogenesis), a natural process that restores blood flow to tissues affected by arteriosclerotic vascular disease. Understanding these mechanisms may lead to new treatments for ischemic conditions.

Keywords:
angiogenesisarteriogenesiscollateral arterygrowthmacrophagesmonocytesremodelingvascular

More Related Videos

Multiphoton Intravital Imaging for Monitoring Leukocyte Recruitment during Arteriogenesis in a Murine Hindlimb Model
07:50

Multiphoton Intravital Imaging for Monitoring Leukocyte Recruitment during Arteriogenesis in a Murine Hindlimb Model

Published on: September 30, 2021

Related Experiment Videos

Last Updated: May 17, 2026

Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis
07:05

Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis

Published on: May 17, 2015

Multiphoton Intravital Imaging for Monitoring Leukocyte Recruitment during Arteriogenesis in a Murine Hindlimb Model
07:50

Multiphoton Intravital Imaging for Monitoring Leukocyte Recruitment during Arteriogenesis in a Murine Hindlimb Model

Published on: September 30, 2021

Area of Science:

  • Cardiovascular Research
  • Immunology
  • Vascular Biology

Background:

  • Arteriosclerotic vascular disease is a leading cause of mortality and morbidity globally.
  • Tissue ischemia and necrosis resulting from this disease affect vital organs like the heart, brain, and limbs.
  • Arteriogenesis, the growth of collateral arteries, is a natural compensatory mechanism to restore blood flow to ischemic tissues.

Purpose of the Study:

  • To review the current evidence regarding the involvement of monocytes and macrophages in collateral artery growth (arteriogenesis).
  • To explore the potential therapeutic implications of understanding these cellular mechanisms for treating ischemic vascular diseases.

Main Methods:

  • Literature review of studies investigating the role of monocytes and macrophages in arteriogenesis.
  • Analysis of experimental and clinical data on immune cell involvement in collateral vessel development.

Main Results:

  • Monocytes and macrophages are integral to the process of arteriogenesis.
  • These immune cells contribute to the inflammatory and remodeling processes essential for collateral artery formation.

Conclusions:

  • Targeting monocyte and macrophage functions presents a promising therapeutic strategy for enhancing arteriogenesis.
  • Further research into the specific roles of these cells could unlock novel treatments for patients suffering from ischemic vascular disease.