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Retinopathy of prematurity in infants with late retinal examination
S Zeinab Mousavi1, Reza Karkhaneh, Mohammad Riazi-Esfahani
1Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Insights
Late screening for retinopathy of prematurity (ROP) in premature infants revealed a high incidence of severe ROP. Timely ROP examinations are crucial for preventing vision loss in vulnerable newborns.
Area of Science:
- Ophthalmology
- Neonatology
- Public Health
Background:
- Retinopathy of prematurity (ROP) is a significant cause of vision impairment in premature infants.
- Delayed screening for ROP can lead to advanced disease and irreversible vision loss.
- Understanding risk factors and incidence is crucial for effective ROP management.
Purpose of the Study:
- To determine the incidence and severity of ROP in premature infants.
- To identify risk factors associated with ROP development.
- To evaluate ROP outcomes in infants with late screening at Farabi Eye Hospital.
Main Methods:
- Retrospective review of hospital records for premature infants screened for ROP.
- Data collected from January 2001 to July 2007.
- Analysis included infant demographics, gestational age, birth weight, and various medical interventions.
Main Results:
- 27.1% of infants had late ROP examinations (mean age 141.7 days).
- 40.3% of these infants presented with ROP, with 16.2% having untreatable stage 5 ROP.
- Lower gestational age, respiratory distress syndrome, and blood transfusion were linked to ROP development.
Conclusions:
- The prevalence of ROP, especially severe ROP, is high with delayed screening.
- Urgent interventions are needed to ensure timely ROP screening for premature infants.
- Optimizing referral pathways can improve ROP outcomes and prevent severe visual impairment.
Purpose:
To report the incidence, severity and risk factors of retinopathy of prematurity (ROP) in premature infants with late ROP examination in Farabi Eye Hospital.
Methods:
In a retrospective study from January 2001 to July 2007, hospital records of premature infants who were examined later than 9 weeks after birth were reviewed to determine the incidence, severity and possible risk factors of ROP including gender, singleton or multiple gestations, gestational age (GA), birth weight (BW), oxygen therapy,blood transfusion, phototherapy, respiratory distress syndrome (RDS), mechanical ventilation,intraventricular hemorrhage and sepsis as well as age at initial examination.
Results:
Out of a total of 797 infants referred for ROP screening during the study period,216 (27.1%) had late examinations at a mean age of 141.7± 150.4 (range 64-1,460) days. Of these, 87 (40.3%) had different stages of ROP, 65 (30.1%) had stage 4 or 5 disease including 34 (16.2%) infants with stage 5 ROP in both eyes which was untreatable. Lower GA (P<0.001), RDS (P=0.041) and blood transfusion (P=0.009) were associated with the development of ROP.
Conclusion:
The overall prevalence of ROP and the incidence of severe ROP in particular,were unacceptably high in premature infants with late screening. These findings necessitate interventions to optimize timely referral for screening of premature infants.
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