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Reinfection Rate after Successful Helicobacter pylori Eradication in Children

Mehri Najafi1, Mohammad Sobhani, Ahmad Khodadad

  • 1Department of Pediatrics, Tehran University of Medical Sciences, Tehran, IR Iran ; Children's Medical Center, Pediatrics Center of Excellence, Tehran, IR Iran.

Iranian Journal of Pediatrics
|October 12, 2012
PubMed

Insights

Helicobacter pylori reinfection occurred in 14.7% of Iranian children after treatment. Successful eradication reduced symptoms, but follow-up is crucial, especially if symptoms persist post-treatment.

Area of Science:

  • Pediatric Infectious Diseases
  • Gastroenterology
  • Microbiology

Background:

  • Helicobacter pylori (H. pylori) reinfection rates are typically low in developed nations.
  • Understanding H. pylori recurrence in pediatric populations in developing countries is essential.

Purpose of the Study:

  • To determine the reinfection rate of H. pylori in Iranian children over a 12-month follow-up period.
  • To assess the long-term efficacy of H. pylori eradication therapy in pediatric patients.

Main Methods:

  • A prospective study involving children treated with an omeprazole-based triple regimen for H. pylori.
  • Utilized the (13)C urea breath test (UBT) for initial eradication confirmation (8 weeks post-therapy) and follow-up (12 months).

Main Results:

  • Out of 37 pediatric patients (aged 5-17 years), 34 achieved initial H. pylori eradication.
  • A reinfection rate of 14.7% was observed within the 12-month follow-up period.
  • Persistent or recurrent symptoms were significantly associated with a higher recurrence rate (P=0.042).

Conclusions:

  • The recurrence rate of H. pylori in this cohort of Iranian children was notably high.
  • Successful eradication therapy led to a significant decrease in patient complaints and symptoms.
  • Regular follow-up and reevaluation are recommended, particularly for children experiencing post-treatment symptoms.
Abstract

Keywords:
Breath TestFurazolidoneGastritisHelicobacter PyloriOmeprazolePeptic Ulcer

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