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Dapsone as an alternative therapy in children with familial mediterranean Fever

Farhad Salehzadeh1, Sepideh Jahangiri, Elnaz Mohammadi

  • 1Department of Pediatrics, Ardabil University of Medical Sciences, Ardebil, Iran.

Iranian Journal of Pediatrics
|October 12, 2012
PubMed
Abstract

Insights

Dapsone controlled Familial Mediterranean Fever (FMF) attacks in 50% of children who couldn't tolerate colchicine. This anti-inflammatory drug shows promise as an alternative therapy for resistant FMF cases.

Area of Science:

  • Rheumatology
  • Pediatrics
  • Genetics

Background:

  • Familial Mediterranean Fever (FMF) is a hereditary autoinflammatory disease characterized by recurrent febrile attacks and polyserositis.
  • Colchicine is the primary treatment, but 5-10% of patients exhibit resistance or intolerance.
  • Alternative therapies are needed for colchicine-resistant FMF.

Purpose of the Study:

  • To evaluate the efficacy of Dapsone as an anti-inflammatory agent in pediatric patients with FMF who are intolerant to colchicine.
  • To explore Dapsone's potential as an alternative treatment option for FMF.

Main Methods:

  • A case series study involving 10 pediatric patients diagnosed with FMF.
  • Patients met the Tel-Hashomer criteria and had poor tolerance or response to colchicine.
  • Dapsone was administered at a dosage of 2mg/kg in a single daily dose for a minimum of 6 months.

Main Results:

  • Five out of ten patients (50%) experienced no FMF attacks during an average follow-up of 8 months and 6 days while on Dapsone.
  • Four patients discontinued Dapsone due to the recurrence of episodic attacks after approximately 27 days.
  • One patient withdrew from the study.

Conclusions:

  • Dapsone demonstrated efficacy in controlling episodic attacks in 50% of pediatric FMF patients with colchicine intolerance.
  • Dapsone may be considered a viable alternative therapeutic option for FMF cases refractory to colchicine treatment.
Keywords:
ChildrenDapsoneFamilial Mediterranan FeverPeriodic Fever

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